Schoen FJ,等在其研究中 ，使用經戊二醛預處理的牛心包材料在植入大鼠皮下8周（56天）后，鈣化程度達到200μg/mg。
欣吉特的瓣膜組織在8周大鼠皮下植入中的鈣化實驗結果優(yōu)良，瓣膜鈣化量遠小于以上這些實驗研究中的經抗鈣化或未經抗鈣化處理的瓣膜材料。并且在后續(xù)的動物實驗及臨床實驗中均未見與鈣化相關的不良事件。
1.Schoen FJ, Tsao JW, Levy RJ. Calcification of bovine pericardium used in cardiac valve bioprostheses. Implications for the mechanisms of bioprosthetic tissue mineralization. Am J Pathol. 1986 Apr;123(1):134-45.
2.Crystal M. Cunanan, Lillian Quintero, Michael N. Helmus, Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby. Patent No.: US 6214054B1, Apr.10, 2001優(yōu)良優(yōu)良
